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Mitochondrial metabolism has also been suggested to be critical to NK function

1993 Sep;92(3):1436-43

This respiratory burst is essential for the destruction of pathogens [47]

10.1016/j.jmb.2010.12.039 52 NirgudeS.ChoudharyB

If obvious medical conditions like heart disease, diabetes, autoimmune conditions are ruled out most physicians assume fatigue is a symptom of depression Though that can be the case, in the majority of medical visits where fatigue is the main complaint an underlying cause can be identified using the concepts of integrative medicine Fatigue is one of the most common reasons for medical evaluation, with up to 35% of all primary care visits for problems of fatigue and tiredness