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Mechanism in eye health: Promotes blood vessel formation improving retinal perfusion

With a higher proportion of senescent cells in the elderly, deficiencies in the respiratory chain functions may develop eventually and may be associated with a decline in mitochondrial respiratory efficiency [9]

133 , e14 (2013)

GLS is highly expressed in various malignancies and has been widely studied as a target for cancer therapy

A similar reasoning can be used for autophagy modulation with lithium-based compounds, which was of no benefit in mouse models and had limited impact in human trials [88]