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Moreover, microbiota-based therapies such as fecal microbiota transplantation have shown promise for certain conditions, but their broader implementation faces practical and translational challenges, including donor variability and screening burden, safety concerns, potential transmission risks, difficulties in standardization (preparation, dosing, and delivery routes), regulatory constraints, and uncertain long-term durability of engraftment and clinical benefit [37]

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Glutathione is naturally produced in the liver and is considered one of the bodys most important antioxidants, responsible for neutralising free radicals, supporting detoxification, and reducing oxidative stress

When these functions break down in advanced CKD, multiple biochemical disturbances may develop

The integration of advanced imaging techniques and metabolomic profiling could further enable real-time monitoring of recovery processes and support the design of personalized therapies based on individual metabolic responses

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