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GlyT1 is expressed predominantly, but not exclusively, in glial cells and is also present in glutamatergic neurons, supporting the view that a major function of GlyT1 is to regulate extracellular glycine levels at synapses and thereby modulate NMDAR activity

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The activation of de novo ser/gly synthesis pathway has been observed, both because of serine synthesis gene amplifications and alterations of upstream regulators that promote enhanced enzyme overexpression

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refrigerate the reconstituted solution and use within 2-4 weeks