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Thus, it may play a role in the pathogenesis of not only AS, but also in a range of neurodevelopmental disorders like fragile X syndrome, Rett syndrome, and other autistic disorders in which mitochondrial dysfunction and oxidative stress were shown to be involved [82,83,84,85]

Free radicals, being electrically charged, tend to damage other molecules, in some cases even forming chain reactions and converting the affected molecules into free radicals as well

For instance, metformin, is generally well-tolerated but can cause gastrointestinal side effects (e.g., nausea, diarrhea) and, in rare cases, lactic acidosis, particularly in patients with renal impairment [118]

Melatonin was found to enhance the nuclear concentrations of activated nuclear factor-E2-related factor (Nrf2) which amplified the expression of antioxidant enzymes, i.e