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Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo

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Emerging targets in photopharmacology

Although several theories with empirical support tackle the point, the causes of BIPN are multifactorial and not fully understood, it remains a potentially persistent adverse event that can lead to long-term objective neurological dysfunction (Li et al., 2020), thereby reducing the quality of life, weakening physical function, causing delays or dose reductions in chemotherapy, and in some cases even interrupting treatment, imposing a huge economic burden (Selvy et al., 2021)

Beneath the epidermis, the dermis provides structural support and elasticity, primarily composed of collagen and elastin fibers

However, biological systems are not at equilibrium and kinetic parameters will ultimately determine which reactions occur in vivo , even though they are thermodynamically unfavorable [26,27]