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A 2016 study published in the International Journal of Molecular Sciences (PMC4881455) specifically compared two forms in melanocyte cell models: GSH reduced glutathione, the standard cosmetic form GSH-MEE glutathione monoethyl ester, a cell-penetrating derivative The conclusion: "GSH-MEE was effective for anti-melanogenesis, whereas GSH itself was not." The reason proposed: free GSH is polar and charged at physiological pH

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