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Curcumin, another promising compound, inhibits NLR family pyrin domain-containing 3 (NLRP3) inflammasome-mediated spinal inflammation, enhances NRF2/GPX4 antioxidant responses, and reduces mitochondrial ROS production

However, first-generation EGFR-TKIs generated disappointing response rates in the treatment of HNSCC [5]

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Despite breakthroughs in our knowledge of the MS onset and progression, effective treatments for progressive disease remain scarce due to several factors which are mentioned in Table 1

This condition differs from tolerance, which is the need for increasing doses of opioids to maintain a defined effect (see Dependence)