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The researchers developed a strain of mice that totally lacked this gene in order to study what happens when its missing

Studies have demonstrated that the inhibition of the MAPK/ERK pathway can promote oligodendrocyte generation and recovery in demyelinating diseases, suggesting a potential therapeutic approach for DN (Suo et al., 2019)

Furthermore, TP53 acts as a mediator between apoptosis and ferroptosis

Upon IB degradation, NF-B is released and translocates into the nucleus, where it recruits p300, which in complex with cAMP response element-binding protein acetylates RelA/p65, thereby activating NF-B transcription and enhancing the expression of downstream pro-inflammatory genes (Lawrence 2009)

Statistics and reproducibility All graphical representations were performed in Adobe Illustrator 29.3.1, with statistic and data representations performed in Prism v10.4.2, if not indicated otherwise