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It was originally developed from research on the pineal gland, specifically from work studying how pineal extracts regulate aging and immune function

In particular, the Cagri-AMY 3 R complex maps displayed weaker density of the RAMP3 ECD, and the complete ECD is only visible in its entirety in the ECD-focused map at high contour level, indicative of a higher dynamics of the AMY 3 R ECD relative to the receptor core (Fig

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