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Moreover, we validated the relationship between GSH-regulated replication stress and JMF4073 sensitivity in a number of TKI-insensitive human CML blast-crisis cells, and present the evidence of the synthetic lethality by targeting glutathione biosynthesis with JMF4073 in these cells

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Du S, Zhang X, Jia Y, Peng P, Kong Q, Jiang S, et al

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This disorder may eventually progress to total loss of scalp hair (alopecia totalis) and total loss of all body hair (alopecia universalis)

Additionally, tumor-targeted ultra-small hybrid C dots have been utilized for this purpose