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People with GI disorders like Crohns syndrome and celiac disease are often unable to break down and absorb dietary B12 and oral B12 supplements, leaving them deficient

It's a key compound in studies on sarcopenia (age-related muscle loss) because of its role in promoting muscle cell function and regeneration

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Vitamin B12 is important in DNA synthesis, red blood cell formation, homocysteine metabolism and the production of S-adenosylmethionine (SAMe)

Moreover, up to 20% to 40% of patients with vascular pathologies present moderate to intermediate hyperhomocysteinemia

Understanding tesofensine's unique mechanism and risk profile helps determine if this powerful but controversial weight loss compound merits consideration despite its FDA rejection and safety concerns