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10.1016/j.jacc.2005.09.068 14

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The oldest patient developed intractable seizures at the age of 3 and continues to be treated with anticonvulsants to reduce the occurrence of breakthrough seizures

Such diseases often arise from impaired vascular function, leading to severe complications such as myocardial infarction and cerebrovascular accidents (Prakash Babu et al., 2019