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Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network

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Metformin attenuated the progression of OA in an MIA-induced mouse model To further investigate the effect of metformin on OA progression, radiological assessments, histological analyses and plasma assays were conducted to evaluate subchondral bone remodeling, articular cartilage degradation, and inflammation at 8 weeks post-MIA injection

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It is often used under provider guidance as part of a structured anti-aging regimen