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Proceedings of the National Academy of Sciences of the United States of America, 107 (36), 1568115686

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CR impacts mitochondrial function and energy metabolism by upregulating superoxide dismutase 2 and activating the AMPK/silent information regulator sirtuin 1/Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha signaling pathway (Vo et al

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With the deepening of studies on the mechanism of ferroptosis, it has been found that ferroptosis plays a role in various biochemical reactions such as cell growth, energy metabolism, and DNA synthesis repair, which are associated with the development of lung diseases ( Figure 1 In this paper, the mechanism of ferroptosis, the research progress of ferroptosis in a variety of lung diseases, and the related signaling pathways and proteins are targeted to provide new ideas and insights for the prevention and treatment of lung diseases in clinical practice ( 2 Characteristics and mechanisms of ferroptosis 2.1 Iron overload Iron is an essential trace element in the body, and iron overload is a key factor in the development of ferroptosis ( 3+ to Fe 2+ during iron metabolism ( Figure 2 )