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Monoculture refers to the adherent culture of one type of cell, which is the most basic culture method

Radiofrequency (RF) Thermal Ablation involves the placement of microelectrode arrays and the use of high frequency alternating current (about 100 kHz) to the specific area [256]

In terms of clinical subtypes, UMN-predominant ALS shows greater cortical hypointensity compared to LMN-dominant forms, indicating specificity in iron distribution (342, 343)

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Novel levodopa formulations and delivery modes address these issues and include novel oral ER formulations as well as non-oral approaches like an inhalation powder for intrapulmonary delivery for on-demand treatment of OFF-episodes and soluble formulations for continuous subcutaneous infusion to control motor fluctuations