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While the trials reported minimal injection site issues, proper technique remains important for safety

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Symptoms include pain, swelling, limited range of motion, and sometimes bruising

Although promotion of angiogenesis and cell proliferation could entail benefits in the short-term in terms of tissue healing, this could be a double-edged sword, as these same processes are how many cancers initiate and spread

Rotate injection sites to prevent lipohypertrophy from repeated trauma to the same location

Bacterial suspensions for infection were plated in solid agar medium to confirm the CFUs used for in vivo challenges