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While some practitioners may choose localized injections in certain situations, the injection site itself is not always the primary factor determining results

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We further proposed that if a manufacturer submits a complete and timely extension request, and CMS determines that the information submitted warrants an extension of the rebate reduction, the total rebate amount would be reduced by 75 percent for the fifth through eighth calendar quarters for that manufacturer's Part B rebatable biosimilar biological product, in accordance with 427.402(b)(2)

Such effects were only seen when Vitamin C was administered at doses exceeding the levels found in typical diets

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