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Restoration of the intestinal barrier in the pre-phase of arthritis using butyrate or a cannabinoid type 1 receptor agonist inhibits the development of arthritis

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Overview of IR The metabolites of chronic overnutrition, such as high glucose and non-esterified fatty acids (NEFAs), interfere with the activation of insulin receptor and its subsequent IRS-1/PI3K/Akt2 pathways, leading to the development of chronic inflammation in adipose tissue and ectopic lipid deposition in the liver and muscles, along with ERS and oxidative stress, etc

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Week-by-week progression Weeks 1-2: Initial changes focus on hydration and surface texture