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Hence, it is intriguing to speculate that a disturbance of the GSH/GSSG ratio - in our case by gsr-1(RNAi) - affects the SKN-1 dependent expression of GCS-1 via such an S-glutathionylation mechanism in order to replenish the GSH pool and maintain a high GSH/GSSG ratio

91,92 The relationship between AMPK and glycolysis in PCOS is central to metabolic disturbances, particularly in granulosa cells

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Many discussions of Melanotan II describe an initial loading period followed by a maintenance period, meaning pigmentation changes may be approached in phasesfirst aiming to establish visible results, then focusing on sustaining them over time

Chatzichristofi et al, 2023)

doi: 10.1016/j.fsi.2021.11.028