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Gender disparities are evident, with males comprising 73.5% of cases, a phenomenon linked to lifestyle factors like smoking and alcohol use, alongside the protective role of estrogen in females

Notably, several of these overlapped with significant MTAs, haplotype-tagging SNPs, and PPI hubs, reinforcing their biological relevance

Azithromycin is recommended for acute OM cases where adherence is difficult or there is no access to refrigeration (Leach et al., 2021), and cefdinir or co-trimoxazole have been recommended for children allergic to penicillin (Siddiq and Grainger, 2015

Chronically low levels render a person more susceptible to recurrent infections, asthma, chronic fatigue syndrome, diabetes, cataracts, cancer, heart disease, premature aging and neurological disorders such as Parkinsons and Alzheimers diseases

1 h later, 1 mL of DCFH-DA was added and incubated with G422 cells for 30 min