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Med Sci Monit 11(6):288 Scholtens RM, van Munster BC, van Kempen MF, de Rooij SEJA (2016) Physiological melatonin levels in healthy older people: a systematic review

Epidemiologic evidence suggests that gut flora disruption due to antibiotic use early in life is associated with an increased risk of developing IBD (258), particularly in the first year of life, as antibiotic use may cause intense and prolonged microbial disruption at a critical time and have long-term effects on the immune system, increasing its risk of future IBD

the process of the invention uses special equipment for crystallisation, as it has been observed that particular stirrers with low shear strength give rise to rapid, complete dissolution of the product in amorphous form and better reproducibility of precipitation, especially when the alpha crystalline form is to be obtained

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Bezabeh T, Mowat MR, Jarolim L, Greenberg AH, Smith IC

This work was further supported by MHRUK and Angharad-Dodds Bursaries to M.B