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Finally, a profound decrease in astrocytic expression of Cx43 was found in the post-mortem samples of patients with advanced-stage PD

Oxidative stress response is clock dependent, as many of the antioxidant enzymes display circadian variations [48,49,50] and BMAL1 plays an important role in their regulation [51]

The relationships of the metabolic pathways are illustrated in Fig

These include reduced gonadotropin secretion due to impaired positive estrogen feedback on luteinizing hormone (LH) secretion in women (21), increased adrenal androgen secretion (22), and direct blockade of gonadotropin action at the gonadal level (23, 24)

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doi: 10.21873/CGP.20021 72 ColellaBColardoMIannoneGContadiniCSaiz-LaderaCFuocoCet al