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Because HepG2 cells possess higher CYPOR activity than primary hepatocytes (Schulz et al

Other inhibitors of RSK include SL0101, LJH685, LJI308 and BIX 02565 which are ATP-competitive inhibitors of the N-terminal kinase domain of RSK, and FMK which is a covalent inhibitor of the C-terminal kinase domain of RSK [10]

R., Murray, A

The translation of findings from rodent models to humans is also often limited by inherent differences in BA metabolism and gut microbiota (147, 163), necessitating rigorous validation in human studies