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Several factors can influence how the MTHFR gene works, resulting in either a clean MTHFR that functions properly or a dirty MTHFR that can cause various health issues

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Jun YH, San Ju G, Chung YY, Shin H-K, Kim D-J, Choi MS, Kim ST, Son KM (2020) Differential expression of vascular endothelial growth factor in the cortex and hippocampus upon cerebral hypoperfusion

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Barakat et al, 2011