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1 The Components of Each CYANOKIT Each CYANOKIT consists of 1 : Dosing and Administration for CYANOKIT Recommended Dosing for CYANOKIT 1 The starting dose of CYANOKIT for adults is 5 g (contained in a single vial), administered by IV infusion over 15 minutes (approximately 15 mL/min)* Depending upon the severity of the poisoning and the clinical response, a second dose of 5 g may be administered by IV infusion up to a total dose of 10 g The rate of infusion for a potential second dose may range from 15 minutes (for patients in extremis) to 2 hours, as clinically indicated *No safety and efficacy studies have been performed in pediatric patients

Drug-induced liver injury Clinical observations APAP overdose is the leading cause of drug-induced liver injury and a major contributor to acute liver failure (ALF) and death worldwide

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