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ALS pathogenic mutations identified in RNA-binding proteins (RBPs) include TAR DNA binding protein 43 (TDP-43), fused-in-sarcoma (FUS), Ewing sarcoma (EWS), TATA-binding protein-associated factor 15 (TAF15), and heterogeneous nuclear ribonucleoproteins (hnRNPs) 5,6

*Correspondence: Galle Friocourt, [email protected] This article was submitted to Neurodevelopment, a section of the journal Frontiers in Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Human activity includes smelting, refining and mining, this may results in lead concentration in the environment

This approach allowed for precise control of live cell positioning and introduced innovative design concepts for fabricating multicellular structures and functional tissues

10.1038/nrd1468 18 BabcockM.De SilvaD.OaksR.Davis-KaplanS.JiralerspongS.MonterminiL.et al (1997)

In this respect, it is plausible that autoimmune responses, which play a role in chronic fatigue syndrome and depression [28, 119] and Long COVID [120], and pulmonary fibrosis with scarring and cardiac remodeling [71] contribute to neuropsychiatric symptoms