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Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD

Sildenafil inhibits hypoxia-induced pulmonary hypertension

The aim of this study was to evaluate the protective effect of glutathione on ROS-mediated DNA damage and apoptosis caused by hydrogen peroxide, H 2 O 2 , in RAW 264.7 macrophages and to investigate the role of the nuclear factor erythroid 2-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway