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This response constitutes the first wave of the inflammatory signal and leads to the upregulation of transcriptional expression of NLRP3,pro-IL-1 and pro-IL-18, thereby preparing the molecular groundwork for inflammasome assembly

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Vzquez N, Vieira CP, Amorim BSR, Torres A, Lpez-Fernndez H, Fdez-Riverola F, et al

Zhang Y, Zeng Y, Huang M, Cao G, Lin L, Wang X, Zhang L, Liu F, Chen J (2024b) Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway

The active element curcumin helps by blocking inflammatory pathways in the body decreasing overall inflammation, which in turn reduces pain