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One subject had only mild learning difficulties and two individuals had normal mental development, but one of them suffered from progressive deterioration of vision, in accordance with progressive optic nerve atrophy

The method of claim 1 , wherein said at least one symptom is selected from the group consisting of: impaired or abnormal gait, neuronal oxidative stress, dementia, tremor, impaired balance, weakness, and personality changes

In the study, we utilized four distinct tau transgenic mouse models including an aggressive, early age onset tauopathy (rTg(tauP301L)4510)Mapt0/0

doi:10.1097/yco.0000000000000527 Nel C, Augustyn L, Bartman N, et al

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