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Hence, we limit ourselves here to reports that have included effects on glutathione status in the overexpressing lines

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Furthermore, this altered metabolism limits mitochondrial reliance and suppresses stress pathways commonly upregulatedand potentially futile upon mitochondrial dysfunction 70,71,72,73,74

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The FDAs LOS encourages the exploratory use of these urinary biomarkers (-GST, CLU, CysC, KIM-1, NGAL, OPN, ALB, and TPRO) as biomarkers of renal tubule injury in early clinical trials. Additionally, the FDA stated that the exploratory human data suggests that the candidate drug-induced renal tubular injury biomarkers may be more sensitive and specific for the detection of acute kidney injury, especially when used in combination, than traditional means of monitoring for nephrotoxicity