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Numerous studies have targeted terpenes that can prevent the expression of anti-apoptotic proteins, such as Bcl-xL, and simultaneously upregulate pro-apoptotic proteins, such as caspases and Bax, leading to apoptosis and cell death, such as betulinic acid, which can upregulate the intrinsic apoptotic pathway by downregulating anti-apoptotic proteins (Liu et al., 2019

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