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Furthermore, GDF15 has been implicated in disorders associated with central sensitization, highlighting its relevance to FM pathophysiology 11

12,13 The disadvantage of absorbable artificial implants is that patients must sacrifice their tissue and adapt even if insufficient tissue wraps around the damaged nerve

This decreased sensitivity is due to the cold tumor effect that CAFs confer, caused by the recruitment of Tregs via TGF, MDSCs via complement signaling, and CXCL16 and CTL exclusion ( The key role played by CAFs in TNBC opens the door to new therapeutic strategies that target CAFs, such as fibroblast grow factor receptor (FGFR) blockade with erdafitinib