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Germline and somatic N F1 gene mutations in plexiform neurofibromas

Thalidomide is widely used in newly diagnosed, relapsed, or refractory MM, especially as maintenance therapy after autologous stem cell transplantation (ASCT)

These ZP modifications primarily serve as morphological markers of an aged follicular microenvironment, which is rooted in age-impaired cumulus-oocyte communication and compromised cytoplasmic maturation of the oocyte

The most common variant is UGT1A1*28 (rs8175347), a promoter polymorphism where the normal (TA)6 repeat in the TATA box is expanded to (TA)7