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S., Burgeiro, A., Garcia, R., Moreno, A

suppresses growth and metastasis of colorectal cancer cells by inhibiting M2 macrophage polarization via a Sp1/ZFAS1/miR-153-3p/CCR5 regulatory axis

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In immunocompetent mice, inhibiting ferroptosis can eliminate the suppressive activity of PMN-MDSCs, slow tumor progression, and synergize with immune checkpoint blockade to suppress tumor growth ( in vitro

Although a higher level of G6PD derived NADPH in the pravastatin group would be expected, its rapid consumption to regenerate GSH may explain similar liver levels in both groups