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If the tissue repair signal driven by FGF2 is abnormally enhanced, although it is helpful for epithelial recovery, it may promote excessive proliferation of fibroblasts and extracellular matrix deposition, potentially initiating the process of pulmonary fibrosis

Staining of alcian blue and periodic acid schiff (PAS) To measure the acid and neutral mucins secreted from goblet cells, the paraffin-embedded lung specimens were sectioned to a thickness of 5 m, deparaffinized, stained with alcian blue (Sigma-Aldrich Chemical) for 15 min, and then washed well in running tap water for 2 min

Injection treatment can help in management of achilles tendinitis but steroid injections in to the weight-bearing tendon are best avoided because of risk of tendon rupture

Throughout the kinase reactions, His-RbC (Rb aa: 772928) was used at low micromolar concentrations (0.52 M), while enzyme concentrations were maintained in the low nanomolar range

Leonardo Ferreira, Ph.D