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The visual inspection of the MD trajectories, available on figshare, reveals a satisfactory stability of distances/angles/torsions involving non-standard atoms along the 100 ns timescale, thus demonstrating the reliability of the corresponding bonded parameters

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Notably, Through a feedback mechanism, mTORC1 inhibition may momentarily increase mTORC2 signaling, causing temporary metabolic disruptions during the first phase of treatment (224), which can transiently disrupt metabolism and frequently leads to hyperlipidemia, necessitating concomitant lipid-lowering therapy (237239)

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