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Methods: ELISA assays measuring the matricellular fibrosis marker thrombospondin-2 (TSP2) and the metabolism/fibrosis-related marker insulin-like growth factor binding protein-7 (IGFBP7) were established using combinations of recombinantly expressed protein, commercial and proprietary monoclonal/polyclonal antibodies

Healing happens from 1 to 6 weeks, depending on the size and depth of the lesion

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., 1996) as well as bound to cobalamin and its substrate (PDB 4REQ

At the transcriptional level, TGF- activates activating transcription factor 4 (ATF4) through both Smad3 and PI3KAktmTORC1 pathways [108]