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In summary, by integrating high-content single-cell level imaging analyses with mechanistic studies, extensive preclinical therapeutic experiments and a Phase Ib clinical trial, our studies herein elucidate the AR +/- BCL-2 +/- PCa cell subpopulation dynamics and credentials BCL-2 as a vital therapeutic target in heterogeneous CRPC

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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Lukasova V, Buzgo M, Sovkova V, Dankova J, Rampichova M, Amler E

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