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ANIT is a hepatotoxicant that induces portal edema, parenchymal necrosis, and inflammation of the bile duct epithelium

The patients blood pressure declines within 30 to 60 minutes after an oral dose, the maximum decrease occurring within 2 to 4 hours

Rapid reduction or abrupt discontinuation of opioid analgesics in patients who are physically dependent on opioids has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide

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doi: 10.1038/s41564-021-01009-4 239

The pH titration experiments were performed in 100 mM HEPES, 150 mM NaCl 2 , 0.5 mM MgCl 2 and pH between 6 and 9 adjusted by KOH, with the actual pH measured post-hoc