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Nucleic Acids Res 48(16):91099123 Paupe V, Dassa EP, Goncalves S, Auchre F, Lnn M, Holmgren A et al (2009) Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia

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OS also reduces tetrahydrobiopterin (BH4), a critical cofactor for eNOS, causing it to produce more ROS instead of NO, thereby amplifying endothelial injury (Hernandez-Navarro et al., 2024)