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"We were able to confirm their functions and then look at bigger picture trends, like the relationship of that gene to different kinds of diseases," said Keith Dufault-Thompson, Ph.D., a staff scientist in NLM's Division of Intramural Research (DIR)

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While initiation of motor neuron degeneration appears cell-intrinsic, other cell types including astrocytes, microglia, and T-lymphocytes are key components in the disease progression of ALS, and cell transplantation could more effectively be targeted at replacing these cell types rather than motor neurons

Mol Microbiol 23:203210

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