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Chronic accumulation of senescent cells with age is associated with IVDD pathogenesis in human and multiple model animals

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Structured exercise in obese diabetic patients with chronic kidney disease: a randomized controlled trial

Addressing the problem while tissue retains regenerative capacity offers better outcomes than waiting until degeneration becomes established

Medication adherence Individuals were treated with long-acting injectable (LAI) medications whenever clinically appropriate

This causes excessive extracellular glutamate around the nearby neurons that survived the initial traumatic event, such that these nearby neurons eventually die because of excitotoxicity

Pro-EGCG greatly slows down the development, growth, and formation of new blood vessels in experimental endometriosis, showing that it can both protect cells from damage and stop the growth of new blood vessels (131)