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239 Mitochondrial iron accumulation lead by Fe-S cluster deficiency can further induce iron-mediated ROS increasing and subsequent ferroptosis that due to lipid peroxides accumulation

This result strongly suggests that hGSTA4-4 and hGST5.8 are specifically adapted by human cells for the purpose of detoxifying 4-HNE to abrogate the downstream effects which such a buildup would cause

I will put the finding about my own genome below it as an example of what useful and actionable insights you can get

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Benard, L

It occurs naturally in the cells of plants, animals, and humans