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10.1101/sqb.2011.76.011023 Cold

Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction

Cochran, D

In summary, human SAM studies indicate that hepatic steatosis is associated with epigenetic dysregulation of metabolic and signaling pathways, whereas animal models reveal transcriptional reprogramming involving peroxisome loss, stress responses, and disrupted mitochondrial function

The combination of the PS structural motif with stable radical may lead to stimulation of higher ROS production