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Tumour heterogeneity and a lack of biomarkers offer significant hurdles in overcoming treatment resistance and relapse ( Figure 1 The tumour immune microenvironment (TIME) is made up of a wide range of immune cells, as well as stromal cells, which contribute to its heterogeneity ( Reprogramming the cellular physiology and avoiding immune damage are two recently identified signs of potential universality that have arisen in the last ten years ( Table 1 ( Table 1 Therapies used in clinical practice for the treatment of TNBC