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The upregulation of miR-21 in macrophages, the key cells of the inflammatory response in MASLD, has been associated with a systemic inflammatory response and increased production of proinflammatory cytokines such as IL-1, TNF, and IL-6 [311]

Therefore, ER levels may serve as a critical biomarker for predicting the efficacy of this therapeutic strategy [97]

A lack of antioxidants, such as glutathione, may aggravate cell death in the liver

E.AstashynA.BennettR.BerryA.et al (2022)

The transcellular lipophilic pathway enables small, lipophilic molecules to diffuse across ECs, but limits the range of molecules that can be delivered [21]

2A), already very early in life, at 3 months of age (Fig