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Many studies have demonstrated that rotenone induces apoptosis in SH-SY5Y cells

Ma H, Qu S, Zhai Y, Yang X

Second-generation CARs incorporate a single co-stimulatory signal, such as CD28 or 4-1BB, whereas third-generation CARs combine multiple co-stimulatory motifs to further amplify immune responses

Associations do not necessarily mean the cause-effect relationship

Next Steps: Data Gaps: Clinical human safety data is currently limited to retrospective studies (e.g., sample size of 12) Nih

There is preliminary evidence that non-pharmacological therapies used in mental disorders like ECT are able to induce changes in gut microbiota [241, 242]