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Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

Emerging studies support the functional involvement of p38 MAPK in modulating synaptic plasticity

Moreover, the dietary intake or supplementary intake of L-arginine can increase and restore these nitric oxide levels and improve fertility, detoxification, brain power, and immune functions

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For the study period of 4 weeks, corticosterone was administered to the rats in doses along with their food: 0mg (control group), 150 mg (group II) and 400 mg (group III)/kg of food