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Adams JC, Srivathsan K, Shen WK

Berberine, a phytochemical discussed in this review, undergoes an extensive metabolism process after oral administration which lead to demethylation, demethylenation, reduction, hydroxylation and conjugation, in vivo

Rudnick DA, Perlmutter DH

The introduction of a single His residue into human GSH transferase A1-1 created an unprecedented enzymatic function, suggesting a strategy that may be of broad applicability in the design of new enzymes